Feel Energy · Longevity
MOTS-c
Support cellular energy and metabolic health at the source.
MOTS-c is a peptide naturally produced by your mitochondria, the energy centers of your cells. It's being studied for its role in how the body uses glucose, responds to exercise, and adapts to metabolic stress. If appropriate, your physician may consider MOTS-c as part of a personalized plan focused on energy, metabolism, and healthy aging.
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Treatment overview
Support the signals behind cellular energy
Mitochondria do more than produce energy. They also send signals that help the body regulate metabolism. MOTS-c is one of these signaling peptides, encoded directly in mitochondrial DNA, and its natural levels have been observed to decline with age.
In research, MOTS-c has been studied for its effects on insulin sensitivity, glucose metabolism, and exercise capacity, largely through AMPK, a key cellular energy sensor. Most findings come from laboratory and animal studies, and human data remain limited.
MOTS-c is not FDA-approved, and its safety and effectiveness in people have not been established. If prescribed, your physician will determine whether it's appropriate for you and guide your dose, schedule, and monitoring.
Compounding notice: This is a compounded medication. Compounded drugs are not FDA-approved, and FDA does not review them for safety, effectiveness, or quality before marketing. A prescription and individualized clinician assessment are required. Evidence for clinical benefits of this peptide in humans is limited.
Benefits
Areas of research interest
- Cellular energy
- Metabolic flexibility
- Insulin sensitivity
- Exercise capacity and endurance
- Body composition
- Healthy aging
Treatment support
Tools and
resources
- Ongoing Feelrx care and support
- Platform access and educational content
- Clear medication instructions from your care team
- Discreet shipping after physician approval and prescription fulfillment
Selected program
What you are purchasing
- Medical intake + virtual physician consultation
- Review by a U.S. board-certified physician
- Prescription treatment, if approved
- Ongoing Feelrx care and support
Energy, from within.
Explore labs →Questions about treatment
Questions, Answered
MOTS-c is investigational, so individual responses vary and aren't guaranteed. Any changes are typically gradual. Your physician will monitor your response and adjust your plan when appropriate.
NAD+ is a coenzyme cells use to produce energy. MOTS-c is a signaling peptide studied for how it helps cells respond to metabolic demand. They work at different points in cellular metabolism.
Reported effects can include redness or irritation at the injection site, headache, fatigue, or mild stomach discomfort. Long-term safety has not been established, and it is not recommended during pregnancy or breastfeeding. Your physician will review your health history first. Allergic or unexpected reactions are possible. Seek prompt medical advice for a concerning reaction; difficulty breathing or facial or throat swelling requires emergency care.
Bloodwork is not automatically required for every Feelrx treatment. Depending on your health history and treatment, your physician may recommend testing. Labs can also be a helpful way to establish your baseline and track relevant health markers over time. Feelrx offers convenient lab options if you'd like to incorporate testing into your care. A baseline metabolic panel or A1C can help track metabolic markers over time. EXPLORE LABS →
After purchase, you'll complete a medical intake with your health history, current medications, and treatment goals, followed by review and a virtual consultation with a U.S. board-certified physician. If treatment is medically appropriate and approved, your prescription moves to fulfillment and delivery. If the physician does not approve treatment, you'll receive a full refund.
MOTS-c is administered by subcutaneous injection. If prescribed, your physician and Feelrx care team will provide instructions specific to your dose, timing, and injection technique. Use only the dose, frequency, and route on your prescription label, follow pharmacy instructions for storage and disposal, and don't share medication or supplies. Contact your prescriber about any concerns, and don't increase your dose on your own.
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